Wendell Stephenson argues in this issue of The journal that the National Institutes of Health's standards for the treatment of laboratory animals fail to give any guidance concerning human well-being nor do they balance human well-being and animal well-being. Stephenson fails, however, to demonstrate how such a balance is to be known. In arguing for reform he implies greater state control without showing that such control would improve the situation. Indeed there are good reasons to think that such control may (...) be harmful. Keywords: animal well-being, economics, human well-being, state control, Stephenson CiteULike Connotea Del.icio.us What's this? (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Bearing witness is complex, and haunted by the past and the present. It takes place through and within a web of power relations attested by truth telling. This essay suggests that ghosts have the c...

In lieu of an abstract, here is a brief excerpt of the content:354 BOOK REVIEWS (continuously) revisable character, he falls back on an account of theology as rhetoric so as to make the best of a bad job. For persuasion is what we use when we know demonstration is hopeless. As a result, Professor Cunningham's study, which could most usefully have "placed" a variety of theologies of past, present, and, prospectively, future on the spectrum of (onto-) logic, poetic, and rhetoric, (...) concludes instead that theology must regard itself as rhetorical or perish! This inevitably narrows the several services theologies of different kinds can perform for the Church. Imagine how biblical studies would be reduced were the exegete only to treat his text as paraenesis, and never as history or as a symbolic world. Nonetheless, on the way from its (as I find) unsatisfactory startingpoint and to its depressing conclusion, Faithful Persuasion has worthwhile points to make about a number of authors (of various periods) and topics, though it might have made them more persuasively (its author's key term) had the intended audience (middle-brow or academic?) been more clearly viewed in advance. AIDAN NICHOLS, O.P. Blackfriars Cambridge, England Church and Culture: German Catholic Theology, 1860-1914. By THOMAS FRANKLIN O'MEARA, O.P. Notre Dame/London: University of Notre Dame Press, 1991. Pp. x + 260. $35.95 (cloth). " In 1925, Baden's Kultusminister, a Protestant, began an address to the Gorresgesellschaft in Heidelberg by describing this era: ' Brave men like Hertling, Schell, Julius Bachem, and Carl Muth, shook the German Catholic world in order to lead it out of its fortress, to lead it again into the midst of the life and activity of the entire people, even when this seemed at first strange and uncomfortable ' " (pp. 159f.). Even to many theologians, the era in question-the last four decades of the nineteenth century through the outbreak of the "Great War"is comparatively unknown. There has been, of course, renewed interest in prominent theological figures like John Henry Newman, but his German-speaking contemporaries are for the most part strangers to the English-speaking world. And this is the first reason why this book is important: it describes a forgotten world of a century or so ago, yet one whose theological problematic was strikingly similar to our own. The " contours " of this period, deftly described in the first part of this book, were both varied and complex. Politically speaking, during the nineteenth century, " Germany " changed from an assortment of BOOK REVIEWS 355 geographically contiguous minor and medium-sized states to an Empire dominated by Prussia. Such a political re.arrangement had ecclesiastical implications: Roman Catholics, who previously had been the majority in places like Bavaria found themselves a persecuted minority during the Kulturkampf under Bismarck. And like many other victims of persecution, Roman Catholics adopted a "fortress mentality"fearful of Berlin, which was influenced by both the Lutheran Reformation and the Enlightenment, and mesmerized by Rome, which was coming under the increasing influence of neoscholasticism in doctrine and ultramontanism in discipline. German Catholic theologians found themselves in a quandary: what direction should they take? Many, like Joseph Kleutgen, took refuge in Rome; a few, like Joseph Schnitzer, found the appeal of Berlin more attractive; still others, however, tried to steer an independent course in dialogue with the culture of their day. The second and major part of this book focuses on five such theologians: Matthias Joseph Scheeben, Alois Schmid, Paul Schanz, Herman Schell, and Carl Braig. Scheeben (1835-88), "the best known and the most read in the first half of the twentieth century " (p. 53), pursued an independent route in seeking a " transcendent synthesis " incorporating both patristic and idealist thought; indeed, his lengthy Mysteries of Christ"ianity continued to enjoy a certain popularity up till the time of Vatican II, though more as a resource for spiritual reading than as a work of systematic theology. Like Newman, Scheeben's thought was sui generis, "and inspired the most divergent evaluations " (p. 65) ; unlike Newman, Scheeben has few disciples today. In contrast to Scheeben, the other four theologians attempted to emerge from the " fortress " of Roman Catholic defensiveness and to engage the historical and philosophical currents of their age. The... (shrink)

Lee emphasizes the need to better understand the moral relationship between researchers and participants connoted by precision medicine, with the framework of “the gift” offering bioethics a...

Informed by theories of embodied cognition, in the present study, we designed a novel priming technique to investigate the impact of spatial diversity and script direction on searching through concepts in both English and Persian (i.e., two languages with opposite script directions). First, participants connected a target dot either to one other dot (linear condition) or to multiple other dots (diverse condition) and either from left to right (rightward condition) or from right to left (leftward condition) on a computer touchscreen (...) using their dominant hand's forefinger. Following the spatial prime, they were asked to generate as many words as possible using two‐letter cues (e.g., “lo” → “love,” “lobster”) in 20 s. We hypothesized that greater spatial diversity, and consistency with script direction, should facilitate conceptual search and result in a higher number of word productions. In both languages, word production performance was superior for the diverse prime relative to the linear prime, suggesting that searching through lexical memory is facilitated by spatial diversity. Although some effects were observed for the directionality of the spatial prime, they were not consistent across experiments and did not correlate with script direction. This pattern of results suggests that a spatial prime that promotes diverse paths can improve word retrieval from lexical memory and lends empirical support to the embodied cognition framework, in which spatial relations play a crucial role in the conceptual system. (shrink)

It is known that the aging process entails a cognitive decline in certain processes such as attention, episodic memory, working memory, processing speed and executive functions. In recent years, ef...

Coach observation studies conducted since the 1970s have sought to determine the quantity and quality of verbal feedback provided by coaches to their athletes. Relatively few studies, however, have sought to determine the knowledge and beliefs of coaches that underpin this provision of feedback. The purpose of the current study was to identify the beliefs and knowledge that elite team sport coaches hold about providing, receiving and evaluating feedback in their training and competition environments. Semi-structured interviews conducted with 8 coaches (...) were inductively analysed, revealing three broad themes: thinking and learning about feedback, providing feedback, and evaluating feedback. Findings revealed a detailed array of knowledge about feedback across a wide range of sub-topics. Coaches saw feedback as a tool to improve performance, build athlete confidence, help athletes to monitor progress, and as a tool to improve their own performance. Novel insights about evaluating an athlete’s reception of feedback, and tailoring feedback for individual athletes, were provided by coaches. The findings also highlight areas in which future coach education offerings can better support coaches to provide effective feedback. (shrink)

This new and revised edition provides a comprehensive dictionary of Indian philosophical terms. Terms are provided in both devanagari and roman transliteration along with their English translations.

This volume is a state-of-the-art review of the evidence and theory supporting the existence and significance of automatic processes in our daily lives, with chapters by the leading researchers in this field today.

The idea of splitting off cells from embryos to clone human beings sounds so bizarre and dangerous that one would think the practice should not be permitted. A closer look reveals its ethical acceptability.

Our experience of the physical world around us, and of the social environments in which we function, is increasingly mediated by information and communication technology, which is itself evolving ever more rapidly and pervasively. This book presents a coherent and detailed account of why we experience feelings of being present in the physical world and in computer-mediated environments, why we often don't, and why it matters - for design, psychotherapy, tool use and social creativity amongst other practical applications. Since the (...) extent to which presence is experienced in a technology-mediated interactive context can be manipulated by design, and in almost unlimited ways, we can use explorations with mediated presence to provide new insights into the psychology of presence in both the physical and technology-mediated worlds. (shrink)

Ernest Gellner was a multilingual polymath who set the agenda in the study of nationalism and the sociology of Islam for an entire generation of academics and students. This definitive biography follows his trajectory from his early years in Prague, Paris and England to international success as a philosopher and public intellectual. Known both for his highly integrated philosophy of modernity and for combining a respect for nationalism with an appreciation for science, Gellner was passionate in his defence of reason (...) against every for of relativism. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

We studied how people determine when they are in control of objects. In a computer task, participants moved a virtual boat towards a goal using a joystick to investigate how subjective control is shaped by (1) correspondence between motor actions and the visual consequences of those actions, and (2) attainment of higher-level goals. In Experiment 1, random discrepancies from joystick input (noise) decreased judgments of control (JoCs), but discrepancies that brought the boat closer to the goal and increased success (the (...) autopilot) increased JoCs. In Experiment 2, participants raced to the goal against a computer-controlled rival boat while varying levels of noise interfered with each boat. Participants reached the goal more often and rated their own control higher when the computer rival had good control. Subjective control over moving objects depends partly on consistency between motor actions and their effects, but is also modulated by perceived success and competition. -/- Keywords: Control; Action; Feedback; Competition . (shrink)

A questionnaire on business ethics was administered to business professionals and to upper-class business ethics students. On eight of the seventeen situations involving ethical dilemmas in business, students were significantly more willing to engage in questionable behavior than were their professional counterparts. Apparently, many students were willing to do whatever was necessary to further their own interests, with little or no regard for fundamental moral principles. Many students and professionals functioned within Lawrence Kohlberg's stage four of moral reasoning, the law (...) and order stage. Individualism and egoism remain strong patterns in the moral reasoning of many professionals, but they influence moral reasoning patterns among students to a much greater degree. (shrink)

Abstract:I argue for taking John Dewey's pluralistic ethics as a starting point, or embedded practice, from and in which technological innovations are conceptualized, critiqued, designed, tested, and eventually implemented. Dewey reconstructs human reason into operational intelligence where all behavior becomes gradually imaginative. I take Dewey's view of moral deliberation as a basis for a responsible process-based methodology combining creative technological design with the training of imaginative prospection. I further use Dewey's conception of technology that holds that implements, but also (...) ideas and concepts are tools, forms of technology. I end by looking at the educational impact for the creative industries. (shrink)

GUM is a linguistically-motivated ontology originally developed to support natural language processing systems by offering a level of representation intermediate between linguistic forms and domain knowledge. Whereas modeling decisions for individual domains may need to be responsive to domain-specific criteria, a linguistically-motivated ontology offers a characterization that generalizes across domains because its design criteria are derived independently both of domain and of application. With respect to this mediating role, the use of GUM resembles (and partially predates) the adoption of upper (...) ontologies as tools for mediating across domains and for supporting domain modeling. This paper briefly introduces the ontology, setting out its origins, design principles and applications. The example cases for this special issue are then described, illustrating particularly some of the principal differences and similarities of GUM to non-linguistically motivated upper ontologies. (shrink)